Contemporary medical device technologies and therapies are often products of vertically integrated workflows involving benchtop fabrication, preclinical screening, and animal modeling. In this paradigm, the combinatorial complexity of design components leads to consequences with dimensionality, making the rational design of high-performance features (e.g., blood compatibility, tissue integration, and stimuli-responsive properties) inherently difficult. Poor understanding of the underlying structure-function relationships is often achieved, leading to the suboptimal realization of developmental potential.
Bio-inspired approaches to materials design often consider an individual component of biological architecture without further weighing of individual contributions of these factors and their interactions in the highly dimensional biological context. Applying expertise in polymer chemistry, surface modification, and combinatorial design, I investigate strategies towards efficient and informed surveys of complex design spaces for integration into technologies for improved human, veterinary, and environmental health.